Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0WZ9T
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| Former ID |
DNC000409
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| Drug Name |
CGP-44532
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| Synonyms |
CGP-44532; CGP 44532; [(2R)-3-amino-2-hydroxypropyl]-methylphosphinic acid; FUUPFUIGNBPCAY-SCSAIBSYSA-N; AC1NSJP2; 133345-68-3; SCHEMBL185739; GTPL1082; CHEMBL113348; Phosphinic acid, P-[(2R)-3-amino-2-hydroxypropyl]-P-methyl-; CGP 44533; ZINC13742955; LS-106096; P-[3-amino-2(R)-hydroxy-propyl]-P-methyl-phosphinic acid
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| Drug Type |
Small molecular drug
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| Indication | Drug abuse [ICD-11: 6C4G.1Z; ICD-10: F19] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H12NO3P
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| Canonical SMILES |
CP(=O)(CC(CN)O)O
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| InChI |
1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h4,6H,2-3,5H2,1H3,(H,7,8)/t4-/m1/s1
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| InChIKey |
FUUPFUIGNBPCAY-SCSAIBSYSA-N
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| CAS Number |
CAS 133345-68-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Agonist | [2], [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1082). | |||
| REF 2 | Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. | |||
| REF 3 | Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am J Physiol. 1999 Oct;277(4 Pt 1):G867-74. | |||
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