Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0WU1S
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| Former ID |
DIB020029
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| Drug Name |
I-BET151
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| Synonyms |
GSK1210151A
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C23H21N5O3
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| Canonical SMILES |
CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC
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| InChI |
1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
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| InChIKey |
VUVUVNZRUGEAHB-CYBMUJFWSA-N
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| CAS Number |
CAS 1300031-49-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
123047600, 126497302, 136349820, 136946561, 137139512, 144116025, 152258476, 160647311, 160683043, 160859765, 162011757, 163393952, 163843319, 164044971, 170484596, 170484681, 174006346, 174527122, 185998846, 187051820, 189561511, 223391545, 223630419, 223705207, 224621035, 228073473, 242586692, 249730469, 249864793, 250211199, 252070128, 252445238, 252552925, 252819653
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| ChEBI ID |
CHEBI:95083
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bromodomain-containing protein 2 (BRD2) | Target Info | Inhibitor | [1] |
| Bromodomain-containing protein 3 (BRD3) | Target Info | Inhibitor | [1] | |
| Bromodomain-containing protein 4 (BRD4) | Target Info | Inhibitor | [1] | |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of retinoblastoma protein | |||
| WikiPathways | Chemical Compounds to monitor Proteins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33. | |||
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