Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0WK9R
|
|||
| Former ID |
DIB020677
|
|||
| Drug Name |
PF-06447475
|
|||
| Synonyms |
1527473-33-1; PF06447475; 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile; CHEMBL3393348; 3FE; GTPL8054; SCHEMBL15401353; EX-A560; AOB5482; BHTWDJBVZQBRKP-UHFFFAOYSA-N; MolPort-039-137-476; BCP14890; BDBM50059277; s8202; ZINC210747484; AKOS025404704; SB17260; CS-3553; NCGC00390733-02; BC600699; DA-44137; HY-12477; AK174244; QC-11808; FT-0700214; PF 06447475; PF-06447475, > J-690197; 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C17H15N5O
|
|||
| Canonical SMILES |
C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N
|
|||
| InChI |
1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
|
|||
| InChIKey |
BHTWDJBVZQBRKP-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leucine-rich repeat kinase 2 (LRRK2) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.