Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W8HN
|
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| Drug Name |
Bavencio
|
|||
| Drug Type |
Monoclonal antibody
|
|||
| Indication | Merkel cell carcinoma [ICD-11: 2C34; ICD-10: C44] | Approved | [1] | |
| Colon cancer [ICD-11: 2B90.Z] | Phase 3 | [2] | ||
| Gastric adenocarcinoma [ICD-11: 2B72; ICD-9: 151] | Phase 3 | [3] | ||
| Head and neck cancer [ICD-11: 2D42] | Phase 3 | [3] | ||
| Urothelial carcinoma [ICD-11: 2C92.0] | Phase 3 | [3] | ||
| Breast cancer [ICD-11: 2C60-2C65] | Phase 2 | [3] | ||
| Melanoma [ICD-11: 2C30; ICD-9: 172] | Phase 2 | [4] | ||
| Squamous cell carcinoma [ICD-11: 2B60-2D01] | Phase 2 | [3] | ||
| Testicular cancer [ICD-11: 2C80; ICD-9: 186] | Phase 2 | [5] | ||
| Haematological malignancy [ICD-11: 2B33.Y] | Phase 1 | [3] | ||
| Company |
EMD Serono Rockland, MA Pfizer New York, NY
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Programmed cell death 1 ligand 1 (PD-L1) | Target Info | Inhibitor | [5] |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Reactome | PD-1 signaling | |||
| WikiPathways | Costimulation by the CD28 family | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 | |||
| REF 2 | ClinicalTrials.gov (NCT03827044) Avelumab Plus 5-FU Based Chemotherapy as Adjuvant Treatment for Stage 3 MSI-High or POLE Mutant Colon Cancer (POLEM). U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 5 | ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health. | |||
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