Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W6AQ
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| Former ID |
DIB014076
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| Drug Name |
TZP-201
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| Synonyms |
JTZ-2002; IBS-D therapeutic, Tranzyme; Irritable bowel syndrome (diarrhea type) therapeutic, Tranzyme; Motilin antagonists (IBS/ fuctional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/ functional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/diarrhea), Tranzyme
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| Indication | Diarrhea [ICD-11: ME05.1; ICD-9: 787.91] | Investigative | [1] | |
| Company |
Tranzyme Pharma Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Motilin receptor (MLNR) | Target Info | Antagonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). | |||
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