Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W2HD
|
|||
| Former ID |
DNC014900
|
|||
| Drug Name |
Mogamulizumab
|
|||
| Drug Type |
Monoclonal antibody
|
|||
| Indication | Mycosis fungoides [ICD-11: 2B01; ICD-10: C84.0] | Approved | [1] | |
| Sezary syndrome [ICD-11: 2B02; ICD-10: C84.1] | Approved | [1] | ||
| Cutaneous T-cell lymphoma [ICD-11: 2B01; ICD-10: C84.8; ICD-9: 202.1, 202.2] | Phase 3 | [2], [3], [4] | ||
| T-cell leukaemia [ICD-11: 2A90; ICD-10: C86] | Phase 2 | [2], [3], [4] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1/2 | [2], [3] | ||
| Company |
Kyowa Hakko Kirin
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-C chemokine receptor type 4 (CCR4) | Target Info | Inhibitor | [5] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Viral carcinogenesis | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 5 | Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma. Curr Opin Mol Ther. 2010 Dec;12(6):770-9. | |||
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