Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VT8P
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| Former ID |
DAP000489
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| Drug Name |
Famciclovir
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| Synonyms |
FCV; Famciclovirum; Famvir; Oravir; BRL 42810; IN1338; Anti-Farnesyl Rabbit pAb; BRL-42810; Famciclovirum [INN-Latin]; Famvir (TN); Famciclovir [USAN:BAN:INN]; Famciclovir (JAN/USAN/INN); [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; Diacetyl 6-deoxy-9-(4-hydroxy-3-hydroxymethyl-but-1-yl)guanine; 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester); 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester); 2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate; 2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-9-yl)butyl acetate; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine; 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Approved | [1] | |
| Therapeutic Class |
Antiviral Agents
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| Company |
Schering-Plough
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H19N5O4
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| Canonical SMILES |
CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
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| InChI |
1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
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| InChIKey |
GGXKWVWZWMLJEH-UHFFFAOYSA-N
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| CAS Number |
CAS 104227-87-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
626303, 5276651, 7847383, 7979216, 8152111, 11363360, 11365922, 11368484, 11372808, 11374301, 11376646, 11484938, 11488917, 11491490, 11492426, 11494280, 11528705, 12013946, 14899331, 26612822, 26680213, 26719883, 26748972, 26748973, 26758694, 29222459, 46386745, 46507561, 47291220, 47515410, 48415997, 49681753, 50107498, 52712677, 53800778, 56313627, 57321725, 68530529, 81092805, 85173809, 85787983, 92124793, 92308042, 92308372, 92309126, 92710468, 103158204, 103231964, 104253634, 104303176
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| ChEBI ID |
CHEBI:4974
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| ADReCS Drug ID | BADD_D00868 | |||
| SuperDrug ATC ID |
J05AB09; S01AD07
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| SuperDrug CAS ID |
cas=104227874
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -8.474; p = 0.006). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -4.603; p = 0.003). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -8.405; p = 0.012). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.409; p = 0.009). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -9.84; p = 0.006). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -3.022; p = 0.0). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -1.744; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -4.097; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -2.818; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -2.942; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -2.783; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -3.783; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -3.872; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -4.353; p = 0.004). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -2.919; p = 0.0). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -6.893; p = 0.021). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -1.153; p = 0.007). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -4.639; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -3.397; p = 0.0). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -4.096; p = 0.006). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -7.225; p = 0.008). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -8.199; p = 0.01). | |||
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Studied Microbe: Bacteroides WH2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides WH2 (log2FC = -7.95; p = 0.007). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -8.331; p = 0.007). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Odoribacter splanchnicus (log2FC = -1.791; p = 0.003). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.957; p = 0.0). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -2.635; p = 0.006). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -1.383; p = 0.005). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Pretovella copri DSM 18205 (log2FC = -6.857; p = 0.049). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -1.998; p = 0.0). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -6.554; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3] | |||
| Experimental Method | High-throughput screening | |||
| Description | Famciclovir can be metabolized by gut microbiota. | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 4 | Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8. | |||
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