Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0VT0T
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| Former ID |
DIB013066
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| Drug Name |
NLX-P101
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| Synonyms |
RAAV-GAD; STN AAV-GAD gene therapy, Neurologix; Subthalamic nucleus AAV-glutamic acid decarboxylase gene therapy, Neurologix; NLX gene therapy (Parkinson's), Neurologix
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Discontinued in Phase 2 | [1] | |
| Company |
Neurologix Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate decarboxylase (GLUL) | Target Info | Modulator | [2] |
| BioCyc | Glutamate dependent acid resistance | |||
| GABA shunt | ||||
| Glutamine biosynthesis | ||||
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
| Arginine and proline metabolism | ||||
| Glyoxylate and dicarboxylate metabolism | ||||
| Nitrogen metabolism | ||||
| Metabolic pathways | ||||
| Biosynthesis of amino acids | ||||
| Glutamatergic synapse | ||||
| GABAergic synapse | ||||
| Panther Pathway | Glutamine glutamate conversion | |||
| Reactome | Amino acid synthesis and interconversion (transamination) | |||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| TNF alpha Signaling Pathway | ||||
| Neurotransmitter uptake and Metabolism In Glial Cells | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017938) | |||
| REF 2 | NLX-P101, an adeno-associated virus gene therapy encoding glutamic acid decarboxylase, for the potential treatment of Parkinson's disease. Curr Opin Investig Drugs. 2010 Jul;11(7):813-22. | |||
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