Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0VS3W
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| Drug Name |
KAR5585
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| Synonyms |
Rodatristat; Rodatristat [USAN]; UNII-507FY6OL37; SCHEMBL16573975; TZSZZENYCISATO-WIOPSUGQSA-N; 507FY6OL37; Ethyl (3S)-8-(2-amino-6-((1R)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro(4.5)decane-3-carboxylate; (S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate; 2,8-Diazaspiro(4.5)decane-3-carboxylic acid, 8-(2-amino-6-((1R)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4
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| Indication | Pulmonary arterial hypertension [ICD-11: BB01.0; ICD-9: 416] | Phase 1 | [1] | |
| Company |
Karos Pharmaceuticals New Haven, CT
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| Structure |
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Download2D MOL |
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| Formula |
C29H31ClF3N5O3
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| Canonical SMILES |
CCOC(=O)C1CC2(CCN(CC2)C3=CC(=NC(=N3)N)OC(C4=C(C=C(C=C4)Cl)C5=CC=CC=C5)C(F)(F)F)CN1
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| InChI |
1S/C29H31ClF3N5O3/c1-2-40-26(39)22-16-28(17-35-22)10-12-38(13-11-28)23-15-24(37-27(34)36-23)41-25(29(31,32)33)20-9-8-19(30)14-21(20)18-6-4-3-5-7-18/h3-9,14-15,22,25,35H,2,10-13,16-17H2,1H3,(H2,34,36,37)/t22-,25+/m0/s1
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| InChIKey |
TZSZZENYCISATO-WIOPSUGQSA-N
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| CAS Number |
CAS 1673571-51-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptophan 5-hydroxylase 1 (TPH1) | Target Info | . | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Serotonin and melatonin biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Panther Pathway | 5-Hydroxytryptamine biosynthesis | |||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Tryptophan metabolism | ||||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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