Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0VE2A
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| Drug Name |
US8546370, 17
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| Synonyms |
SCHEMBL1048459; CHEMBL3642578; BDBM103511; US8546370, 17
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H25N5O2
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| Canonical SMILES |
C1COCCN1C2=CC=C(C=C2)NC3=C4C(=CC(=N3)CCCN)C=CNC4=O
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| InChI |
1S/C21H25N5O2/c22-8-1-2-17-14-15-7-9-23-21(27)19(15)20(25-17)24-16-3-5-18(6-4-16)26-10-12-28-13-11-26/h3-7,9,14H,1-2,8,10-13,22H2,(H,23,27)(H,24,25)
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| InChIKey |
MKILIVUEQNFIIU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target's Patent Info | [1] | |
| KEGG Pathway | Ras signaling pathway | |||
| NF-kappa B signaling pathway | ||||
| Natural killer cell mediated cytotoxicity | ||||
| T cell receptor signaling pathway | ||||
| Primary immunodeficiency | ||||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| TCR signaling in naï | ||||
| Class I PI3K signaling events | ||||
| Reactome | Translocation of ZAP-70 to Immunological synapse | |||
| Generation of second messenger molecules | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Interferon type I signaling pathways | ||||
| Inflammatory Response Pathway | ||||
| JAK/STAT | ||||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| TCR signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Compounds and compositions as kinase inhibitors. US8546370. | |||
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