Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VD7H
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| Former ID |
DIB007585
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| Drug Name |
CL-5343
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| Synonyms |
5-Amino-1,3,4-thiadiazole-2-sulfonamide; 14949-00-9; Tio-urasin; CL 5343; UNII-F687N81LIZ; NSC 22979; 2-Amino-1,3,4-thiadiazole-5-sulfonamide; CHEMBL265674; F687N81LIZ; 1,3,4-Thiadiazole-2-sulfonamide, 5-amino-; 5-Amino-TDSNH2; PubChem15758; Acetazolamide Impurity D; AC1Q6UUX; 1,3,4-Thiadiazole-5-sulfonamide, 2-amino-; SCHEMBL282413; AC1L382D; CTK4C6227; BDBM10868; DTXSID10164324; MolPort-022-374-081; VGMVBPQOACUDRU-UHFFFAOYSA-N; NSC22979; ZINC16969869; NSC-22979; 1,3,4-thiadiazole-2-sulfonamide 15; aromatic/heteroaromatic; CL-5343; Carbonic anhydrase inhibitors, Universita degli Studi di Firenze; Sulfonamide CA inhibitors, Universita degli Studi di Firenze; Sulfonamide CA inhibitors, University of Florence; Carbonic anhydrase inhibitors (cancer/epilepsy/glaucoma/obesity); Carbonic anhydrase inhibitors (cancer/epilepsy/glaucoma/obesity), University of Florence/ULS; 5-amino-1,3,4-thiadiazole-2-sulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Company |
Universita degli Studi di Firenze
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| Structure |
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Download2D MOL |
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| Formula |
C2H4N4O2S2
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| Canonical SMILES |
C1(=NN=C(S1)S(=O)(=O)N)N
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| InChI |
1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)
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| InChIKey |
VGMVBPQOACUDRU-UHFFFAOYSA-N
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| CAS Number |
CAS 14949-00-9
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597). | |||
| REF 2 | Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. | |||
| REF 3 | Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. Eur J Med Chem. 2010 Nov;45(11):4769-73. | |||
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