Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V9LF
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| Former ID |
DIB012681
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| Drug Name |
Anti-CD28
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| Synonyms |
Anti-CD28 (immune disease); Anti-CD28 antibody (immune disorder), BMS; Anti-CD28 (immune disease), Bristol-Myers Squibb
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| Drug Type |
Antibody
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| Indication | Immune System disease [ICD-11: 4A01-4B41; ICD-10: D80-D89] | Investigative | [1] | |
| Company |
Bristol-Myers Squibb Co
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | T-cell-specific surface glycoprotein CD28 (CD28) | Target Info | . | [1] |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| T cell receptor signaling pathway | ||||
| Intestinal immune network for IgA production | ||||
| Type I diabetes mellitus | ||||
| Measles | ||||
| Autoimmune thyroid disease | ||||
| Systemic lupus erythematosus | ||||
| Rheumatoid arthritis | ||||
| Allograft rejection | ||||
| Graft-versus-host disease | ||||
| Viral myocarditis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| TCR signaling in naï | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | PIP3 activates AKT signaling | |||
| Constitutive Signaling by Aberrant PI3K in Cancer | ||||
| CD28 co-stimulation | ||||
| CD28 dependent PI3K/Akt signaling | ||||
| CD28 dependent Vav1 pathway | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Inflammatory Response Pathway | ||||
| Host Interactions of HIV factors | ||||
| PIP3 activates AKT signaling | ||||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| Allograft Rejection | ||||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2863). | |||
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