Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V8KI
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| Former ID |
DIB001249
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| Drug Name |
Fenspiride hydrochloride
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| Synonyms |
KSP-193
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Terminated | [1] | |
| Company |
Kissei Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C15H21ClN2O2
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| Canonical SMILES |
C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3.Cl
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| InChI |
1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
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| InChIKey |
FIKFLLIUPUVONI-UHFFFAOYSA-N
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| CAS Number |
CAS 5053-08-7
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| PubChem Compound ID | ||||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.816; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -1.153; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.932; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.922; p = 0.019). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.528; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.909; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.738; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -1.022; p = 0.003). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -1.064; p = 0.009). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.493; p = 0.044). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.53; p = 0.032). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.847; p = 0.021). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.812; p = 0.002). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.747; p = 0.005). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.392; p = 0.039). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Fenspiride can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.511; p = 0.023). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Fenspiride in patients with acute bronchitis. Pol Merkur Lekarski. 2005 Jul;19(109):32-6. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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