Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V7XC
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| Former ID |
DIB009710
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| Drug Name |
R-1518
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| Synonyms |
Levovirin prodrug, Roche
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Discontinued in Phase 1 | [1] | |
| Company |
Roche Holding AG
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| Structure |
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Download2D MOL
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| Formula |
C13H22ClN5O6
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| Canonical SMILES |
CC(C)C(C(=O)OCC1C(C(C(O1)N2C=NC(=N2)C(=O)N)O)O)N.Cl
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| InChI |
1S/C13H21N5O6.ClH/c1-5(2)7(14)13(22)23-3-6-8(19)9(20)12(24-6)18-4-16-11(17-18)10(15)21;/h4-9,12,19-20H,3,14H2,1-2H3,(H2,15,21);1H/t6-,7-,8-,9-,12-;/m0./s1
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| InChIKey |
BZAMJGAXDMZZKX-JSNLFJDGSA-N
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| CAS Number |
CAS 705930-02-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase (IMPDH) | Target Info | Modulator | [2] |
| KEGG Pathway | Purine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | |||
| WikiPathways | Nucleotide Metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018979) | |||
| REF 2 | US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases. | |||
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