Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V6AH
|
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| Former ID |
DIB015023
|
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| Drug Name |
Endostatin
|
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 2 | [1] | |
| Company |
EntreMed
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C9H10N2O2
|
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| Canonical SMILES |
CN(CC(=O)C1=CC=CC=C1)N=O
|
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| InChI |
1S/C9H10N2O2/c1-11(10-13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3
|
|||
| InChIKey |
AAFYOVPTFNNVDN-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 55984-52-6
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prolactin receptor (PRLR) | Target Info | Modulator | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Prolactin signaling pathway | ||||
| Pathway Interaction Database | ErbB4 signaling events | |||
| Signaling events mediated by PTP1B | ||||
| Reactome | Prolactin receptor signaling | |||
| Growth hormone receptor signaling | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Prolactin receptor signaling | ||||
| Growth hormone receptor signaling | ||||
| Adipogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Prolactin antagonist-endostatin fusion protein as a targeted dual-functional therapeutic agent for breast cancer. Cancer Res. 2003 Jul 1;63(13):3598-604. | |||
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