Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V5JO
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| Former ID |
DIB009903
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| Drug Name |
T-0128
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| Synonyms |
M salt; MEN-4901; Glycylglycyl-N-[3-[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yloxy]propyl]glycinamide compound with dextran carboxymethyl ether sodiu
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C87H170N6O26
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| Canonical SMILES |
CCCC.CCCC.CCCC.CCCC.CCCC.CCCC.CCCCNC.CCC1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC3C(C(C(C(O3)OO)OC)O)O)O)O)O)O)O)O.CCC1=CC=NC2=CC=CC=C12.CCC(=O)NCCCOC.CCC1(CCCOC1=O)O.CC(=O)NC.CC(=O)NCC(=O)N.C1C=CC=CC1=O.O
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| InChI |
1S/C20H36O16.C11H11N.C7H15NO2.C7H12O3.C6H6O.C5H13N.C4H8N2O2.6C4H10.C3H7NO.H2O/c1-3-6-9(21)12(24)15(27)18(33-6)31-4-7-10(22)13(25)16(28)19(34-7)32-5-8-11(23)14(26)17(30-2)20(35-8)36-29;1-2-9-7-8-12-11-6-4-3-5-10(9)11;1-3-7(9)8-5-4-6-10-2;1-2-7(9)4-3-5-10-6(7)8;7-6-4-2-1-3-5-6;1-3-4-5-6-2;1-3(7)6-2-4(5)8;6*1-3-4-2;1-3(5)4-2;/h6-29H,3-5H2,1-2H3;3-8H,2H2,1H3;3-6H2,1-2H3,(H,8,9);9H,2-5H2,1H3;1-4H,5H2;6H,3-5H2,1-2H3;2H2,1H3,(H2,5,8)(H,6,7);6*3-4H2,1-2H3;1-2H3,(H,4,5);1H2/t6-,7?,8-,9-,10-,11-,12+,13+,14+,15-,16-,17-,18+,19+,20-;;;7-;;;;;;;;;;;/m1..0.........../s1
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| InChIKey |
HYSLQFLGTWXGPE-JCQKILSGSA-N
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| PubChem Compound ID | ||||
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Inhibitor | [2] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014468) | |||
| REF 2 | Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95. | |||
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