Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V4TV
|
|||
| Former ID |
DIB001352
|
|||
| Drug Name |
CBLB-502
|
|||
| Synonyms |
CBLB-501; Mini-flagellin, Cleveland BioLabs; Recombinant flagellin proteins (injury protection), Cleveland BioLabs
Click to Show/Hide
|
|||
| Indication | Acute radiation syndrome [ICD-11: NF00; ICD-10: T66; ICD-9: 990] | Phase 2 | [1], [2] | |
| Company |
Cleveland BioLabs Inc
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 5 (TLR5) | Target Info | Agonist | [1], [2] |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Pathogenic Escherichia coli infection | ||||
| Salmonella infection | ||||
| Legionellosis | ||||
| Inflammatory bowel disease (IBD) | ||||
| Reactome | MyD88 deficiency (TLR5) | |||
| IRAK4 deficiency (TLR5) | ||||
| MyD88 cascade initiated on plasma membrane | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| MyD88 cascade initiated on plasma membrane | ||||
| Toll-Like Receptors Cascades | ||||
| Pathogenic Escherichia coli infection | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. PLoS One. 2014 May 30;9(5):e96165. | |||
| REF 2 | A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. PLoS One. 2014 Jan 14;9(1):e85587. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.