Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V4RH
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| Former ID |
DCL000308
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| Drug Name |
Lobucavir
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| Synonyms |
LOBUCAVIR; 127759-89-1; Cyclobut-G; C-Oxetanocin-G; C-Oxt-G; BMS-180194; Cygalovir; (+)-Cyclobut G; 2-Amino-9-((1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl)-1H-purin-6(9H)-one; Lobucavir [USAN:INN]; SQ 33054; UNII-8U5PYQ1R2E; SQ 34,514; DRG-0235; 126062-18-8; 8U5PYQ1R2E; SQ-34514; Bms 180194; 9-((1R,2R,3S)-2,3-Bis(hydroxymethyl)cyclobutyl)guanine; C11H15N5O3; Carbocyclic oxetanocin G; A-69992; 2-amino-9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl]-3H-purin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Discontinued in Phase 3 | [1] | |
| Company |
Bristol-Myers Squibb
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H15N5O3
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| Canonical SMILES |
C1C(C(C1N2C=NC3=C2N=C(NC3=O)N)CO)CO
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| InChI |
1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m1/s1
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| InChIKey |
GWFOVSGRNGAGDL-FSDSQADBSA-N
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| CAS Number |
CAS 127759-89-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
596220, 613723, 12014555, 14799097, 14799100, 14823891, 14848169, 15197174, 43118133, 47206573, 50064310, 57314112, 76947285, 104321641, 117596104, 121379603, 128015376, 134222462, 134338964, 134339774, 135022401, 137263759, 160693251, 163124427, 163414517, 163849336, 164761615, 180371253, 189053428, 198975041, 211535682, 223554762, 223657163, 226435100, 240472846, 250216084, 251876846, 252075722, 252430728, 252489108
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002213) | |||
| REF 2 | Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatit... Antiviral Res. 2000 Dec;48(3):197-203. | |||
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