Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V4QS
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| Former ID |
DAP000022
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| Drug Name |
Olanzapine
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| Synonyms |
Lanzac; Midax; Olansek; Olanzapina; Olanzapinum; Symbyax; Zalasta; Zydis; Zyprexa; Eli Lilly brand of olanzapine; Lilly brand of olanzapine; Zyprexa Intramuscular; Zyprexa Velotab; Zyprexa Zydis; LY 170053; ALKS-7921; KS-1090; LY-170052; LY-170053; Olanzapine (OLA); Olanzapine [USAN:INN]; Olzapin (TN); Rexapin (TN); Zalasta (TN); Zolafren (TN); Zydis (TN); Zyprexa (TN); Olanzapine (JAN/USAN/INN); 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno[2,3-b ] [1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Approved | [1], [2] | |
| Therapeutic Class |
Antipsychotic Agents
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| Company |
Eli Lilly
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| Structure |
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Download2D MOL |
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| Formula |
C17H20N4S
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| Canonical SMILES |
CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
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| InChI |
1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
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| InChIKey |
KVWDHTXUZHCGIO-UHFFFAOYSA-N
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| CAS Number |
CAS 132539-06-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9530, 591970, 816938, 5025348, 7847520, 7980183, 11528747, 12014657, 14923451, 25819934, 26612730, 26719852, 26750094, 29215187, 29215188, 29223674, 42684855, 46386668, 46507666, 48416347, 49665994, 49666419, 49681733, 49830782, 53788662, 56310909, 56312010, 56312820, 56352944, 57288797, 57322337, 77029366, 81092909, 85174531, 85209215, 85213702, 85753333, 89736112, 92307994, 92308375, 92308920, 92712529, 93166490, 93167156, 93618268, 99637141, 103195217, 103950390, 104253651, 104306829
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| ChEBI ID |
CHEBI:7735
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| ADReCS Drug ID | BADD_D01599 ; BADD_D01600 | |||
| SuperDrug ATC ID |
N05AH03
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| SuperDrug CAS ID |
cas=132539061
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.538; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.653; p = 0.03). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.653; p = 0.041). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -1.057; p = 0.032). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.46; p = 0.033). | |||
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Studied Microbe: Odoribacter splanchnicus
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Olanzapine can be metabolized by Odoribacter splanchnicus (log2FC = -0.708; p = 0.014). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 47). | |||
| REF 2 | Olanzapine: an updated review of its use in the management of schizophrenia. Drugs. 2001;61(1):111-61. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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