Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UZ4J
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| Former ID |
DIB020914
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| Drug Name |
SB-334867
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| Synonyms |
SB334867A; SB-334,867
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C17H13N5O2
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| Canonical SMILES |
CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
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| InChI |
1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)
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| InChIKey |
AKMNUCBQGHFICM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11114248, 11646547, 14776953, 43224660, 50181534, 58107233, 76715534, 85789055, 91746568, 99373539, 103244336, 109693231, 114638243, 123044251, 123051109, 126582324, 126639237, 126726711, 127419851, 135651005, 135698525, 137235773, 144239941, 160863499, 162023364, 162223693, 162914908, 164224747, 165237896, 179338019, 184603084, 202545652, 210274730, 210280364, 223454742, 223519282, 224108320, 226812185, 241054690, 242059998, 249717062, 251910718, 251961375, 252156216, 252160724, 252475028
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| ChEBI ID |
CHEBI:92733
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orexin receptor type 1 (HCRTR1) | Target Info | Antagonist | [2] |
| Orexin receptor type 2 (HCRTR2) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1703). | |||
| REF 2 | Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. | |||
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