Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UN8H
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| Former ID |
DIB020033
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| Drug Name |
IC261
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| Synonyms |
IC-261; IC 261
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|
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| Drug Type |
Small molecular drug
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| Indication | Pancreatic cancer [ICD-11: 2C10; ICD-9: 157] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C18H17NO4
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| Canonical SMILES |
COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC
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| InChI |
1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+
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| InChIKey |
JBJYTZXCZDNOJW-JLHYYAGUSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Casein kinase I alpha (CSNK1A1) | Target Info | Inhibitor | [2] |
| Casein kinase I delta (CSNK1D) | Target Info | Inhibitor | [2] | |
| Casein kinase I epsilon (CSNK1E) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. | |||
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