Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UL2I
|
|||
| Former ID |
DIB003640
|
|||
| Drug Name |
PF-06427878
|
|||
| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99, E78; ICD-9: 390-459] | Phase 1 | [1] | |
| Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 1 | [2] | ||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol O-acyltransferase 2 (DGAT2) | Target Info | Inhibitor | [1] |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Triacylglyceride Synthesis | |||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT02208284) A Single Oral Dose Study Of PF-06427878 In Healthy Adult Subjects. U.S. National Institutes of Health. | |||
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