Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U9LD
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Former ID |
DIB019233
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Drug Name |
PMID18800762C14
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Synonyms |
bisphosphonate, 14; GTPL3194; BDBM25258
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C18H33NO7P2
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Canonical SMILES |
CCCCCCCCCCOC1=C[N+](=CC(=C1)CC(P(=O)(O)O)P(=O)(O)[O-])C
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InChI |
1S/C18H33NO7P2/c1-3-4-5-6-7-8-9-10-11-26-17-12-16(14-19(2)15-17)13-18(27(20,21)22)28(23,24)25/h12,14-15,18H,3-11,13H2,1-2H3,(H3-,20,21,22,23,24,25)
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InChIKey |
PUCSJEGLZHMUSS-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [1] |
BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
Superpathway of cholesterol biosynthesis | ||||
Trans, trans-farnesyl diphosphate biosynthesis | ||||
Geranylgeranyldiphosphate biosynthesis | ||||
KEGG Pathway | Terpenoid backbone biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Influenza A | ||||
HTLV-I infection | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
SREBP signalling | ||||
Cholesterol Biosynthesis |
References | Top | |||
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REF 1 | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3194). |
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