Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U9IQ
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| Former ID |
DCL001077
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| Drug Name |
PF-477736
|
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| Drug Type |
Small molecular drug
|
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| Indication | Advanced solid tumour [ICD-11: 2A00-2F9Z; ICD-9: 140-199] | Discontinued in Phase 1 | [1], [2] | |
| Company |
Pfizer
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H25N7O2
|
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| Canonical SMILES |
CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2
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| InChI |
1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1
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| InChIKey |
NDEXUOWTGYUVGA-LJQANCHMSA-N
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| CAS Number |
CAS 952021-60-2
|
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| PubChem Compound ID | ||||
| PubChem Substance ID |
26738683, 134339473, 135267502, 135653612, 136920310, 137275976, 142910601, 152258067, 152344328, 160646905, 162009842, 162011615, 162205240, 162249186, 172650635, 174007106, 177749453, 189614649, 198964618, 203090938, 223705255, 238593669, 241376902, 243967249, 251963197, 252157928, 252160096, 252450359, 252543444
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| ChEBI ID |
CHEBI:91385
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8043). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022394) | |||
| REF 3 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | |||
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