Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U7WF
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| Former ID |
DIB018489
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| Drug Name |
16,16-dimethyl-PGE2
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| Synonyms |
16,16-dimethylprostaglandin E2
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| Drug Type |
Small molecular drug
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| Indication | Stem cell engraftment [ICD-11: QB63.8] | Phase 2 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H36O5
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| Canonical SMILES |
CCCCC(C)(C)C(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
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| InChI |
1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1
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| InChIKey |
QAOBBBBDJSWHMU-WMBBNPMCSA-N
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| CAS Number |
CAS 39746-25-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4265999, 11038723, 14780130, 15990197, 22395646, 24893214, 26754817, 26754818, 39316483, 47211768, 48258966, 50110788, 56459057, 56459353, 77442172, 91703663, 92309781, 99234253, 99300695, 99302213, 104046444, 104242283, 113858994, 135651380, 162227826, 163685804, 177748431, 179205571, 198989304, 226969995, 241376771, 250132932, 252157723, 252455505, 252457331
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| ChEBI ID |
CHEBI:141046
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin E2 receptor EP2 (PTGER2) | Target Info | Agonist | [2] |
| Prostaglandin E2 receptor EP3 (PTGER3) | Target Info | Agonist | [2] | |
| Prostaglandin E2 receptor EP4 (PTGER4) | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Regulation of lipolysis in adipocytes | ||||
| Pathways in cancer | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Renin secretion | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (i) signalling events | ||||
| G alpha (s) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Ovarian Infertility Genes | ||||
| Vitamin D Receptor Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | |||
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