Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U7OO
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Former ID |
DIB018673
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Drug Name |
6-fluoromevalonate 5-diphosphate
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Synonyms |
GTPL3205; 6-fluoro-3-hydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylhexanoic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C7H15FO10P2
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Canonical SMILES |
CC(CC(CF)OP(=O)(O)OP(=O)(O)O)(CC(=O)O)O
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InChI |
1S/C7H15FO10P2/c1-7(11,3-6(9)10)2-5(4-8)17-20(15,16)18-19(12,13)14/h5,11H,2-4H2,1H3,(H,9,10)(H,15,16)(H2,12,13,14)
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InChIKey |
YGLNCOGHKIHKSA-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Diphosphomevalonate decarboxylase (MVD) | Target Info | Inhibitor | [2] |
BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
Superpathway of cholesterol biosynthesis | ||||
Mevalonate pathway | ||||
Panther Pathway | Cholesterol biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
SREBP signalling | ||||
Cholesterol Biosynthesis | ||||
Cholesterol biosynthesis |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3205). | |||
REF 2 | Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67. |
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