Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U5FS
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| Former ID |
DAP000980
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| Drug Name |
Fluspirilene
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| Synonyms |
Fluspirilen; Fluspirileno; Fluspirilenum; Imap; Redeptin; Spirodiflamine; R 6218; F-100; Fluspirileno [INN-Spanish]; Fluspirilenum [INN-Latin]; Imap (TN); Spiropiperidine analogue, 1; Fluspirilene (USAN/INN); Fluspirilene [USAN:INN:BAN]; McN-JR-6218; 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane; 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one; 8-[4,4-bis (p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4,5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one; 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Approved | [1], [2] | |
| Therapeutic Class |
Antipsychotic Agents
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| Company |
Janssen Pharmaceutica
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| Structure |
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Download2D MOL |
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| Formula |
C29H31F2N3O
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| Canonical SMILES |
C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
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| InChI |
1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
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| InChIKey |
QOYHHIBFXOOADH-UHFFFAOYSA-N
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| CAS Number |
CAS 1841-19-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5373984, 8152165, 11111163, 11112501, 11466934, 11468054, 11486687, 11532937, 15034182, 17396799, 17405081, 24277915, 26753577, 26753578, 29222531, 46508202, 47365394, 47365395, 47440449, 47515499, 47662490, 48185163, 48185164, 49699203, 50055682, 50106303, 50106304, 50106305, 50549166, 53777624, 56422781, 57298659, 57321776, 81093250, 85086165, 85209874, 85231040, 85788238, 90341058, 92125718, 92303784, 92308731, 92309759, 99300673, 103224650, 103914601, 104171151, 104303392, 121361281, 121363389
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| ChEBI ID |
CHEBI:93369
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| SuperDrug ATC ID |
N05AG01
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| SuperDrug CAS ID |
cas=001841196
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Eubacterium rectale
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Fluspirilen (adjusted p-values: 9.48E-03). | |||
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Studied Microbe: Roseburia intestinalis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Fluspirilen (adjusted p-values: 3.93E-04). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 85). | |||
| REF 2 | Drug information of Fluspirilene, 2008. eduDrugs. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Inhibition of glutamate release by fluspirilene in cerebrocortical nerve terminals (synaptosomes). Synapse. 2002 Apr;44(1):36-41. | |||
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