Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U5BF
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| Former ID |
DIB008446
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| Drug Name |
ALPHA-FMH
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| Synonyms |
Alpha-(Fluoromethyl)histidine
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| Drug Type |
Small molecular drug
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| Indication | Pruritus [ICD-11: EC90; ICD-10: L29, L29.9; ICD-9: 698] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C7H10FN3O2
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| Canonical SMILES |
C1=C(NC=N1)CC(CF)(C(=O)O)N
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| InChI |
1S/C7H10FN3O2/c8-3-7(9,6(12)13)1-5-2-10-4-11-5/h2,4H,1,3,9H2,(H,10,11)(H,12,13)
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| InChIKey |
AJFGLTPLWPTALJ-UHFFFAOYSA-N
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| CAS Number |
CAS 70050-43-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histidine decarboxylase (HDC) | Target Info | Modulator | [2] |
| KEGG Pathway | Histidine metabolism | |||
| Metabolic pathways | ||||
| Panther Pathway | Histamine synthesis | |||
| CCKR signaling map ST | ||||
| Pathwhiz Pathway | Histidine Metabolism | |||
| WikiPathways | Biogenic Amine Synthesis | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5189). | |||
| REF 2 | Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9. | |||
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