Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U3YU
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| Former ID |
DIB005447
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| Drug Name |
Ademetionine
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| Synonyms |
Ceritan; Samyr; Transmetil; Ademetionine butandisulphonate; Ademetionine disulfate tosylate; Ademetionine sulfate tosilate; FD-1561; FO-1561
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| Drug Type |
Small molecular drug
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| Indication | Hepatic fibrosis [ICD-11: DB93.0; ICD-10: K74.0; ICD-9: 709.2] | Approved | [1] | |
| Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Phase 4 | [2], [3] | ||
| Company |
Bioresearch SpA
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| Structure |
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Download2D MOL |
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| Formula |
C15H22N6O5S
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| Canonical SMILES |
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
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| InChI |
1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1
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| InChIKey |
MEFKEPWMEQBLKI-AIRLBKTGSA-N
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| CAS Number |
CAS 29908-03-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
584705, 584819, 585530, 585647, 819953, 820416, 822522, 827273, 827276, 827431, 827923, 827984, 828011, 828013, 828789, 830207, 831396, 831453, 831806, 831932, 832635, 833168, 834388, 834611, 834731, 838314, 838315, 6435774, 6435784, 8017006, 8018772, 8024112, 8028062, 8145813, 8147098, 8147099, 8173805, 10318367, 10318534, 10322395, 10322405, 11532836, 11538426, 14709946, 14716693, 16477986, 17404326, 17422915, 17422968, 17422983
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| ChEBI ID |
CHEBI:67040
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transferase unspecific (TF) | Target Info | Modulator | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2013 | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4786). | |||
| REF 3 | ClinicalTrials.gov (NCT01998620) Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis. U.S. National Institutes of Health. | |||
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