Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U1SI
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| Former ID |
DIB017008
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| Drug Name |
Bimoclomol
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| Synonyms |
ABT-822; BRLP-42; BRX-211
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Discontinued in Phase 2 | [1] | |
| Company |
CytRx; Biorex Research and Development Co
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| Structure |
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Download2D MOL |
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| Formula |
C14H20ClN3O2
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| Canonical SMILES |
C1CCN(CC1)CC(CON=C(C2=CN=CC=C2)Cl)O
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| InChI |
1S/C14H20ClN3O2/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18/h4-6,9,13,19H,1-3,7-8,10-11H2/b17-14-
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| InChIKey |
NMOVJBAGBXIKCG-VKAVYKQESA-N
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| CAS Number |
CAS 130493-03-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Heat shock protein 70 (HSP70) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004241) | |||
| REF 2 | Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7. | |||
| REF 3 | Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats. Eur J Pharmacol. 2002 Jan 18;435(1):79-83. | |||
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