Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U0NT
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Former ID |
DNC008346
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Drug Name |
ER-119884
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Synonyms |
ER-119884; CHEMBL258503; (3r)-3-{[2-Benzyl-6-(3-Methoxypropoxy)pyridin-3-Yl]ethynyl}-1-Azabicyclo[2.2.2]octan-3-Ol; ER4; SCHEMBL6377294; BDBM50208577; (R)-3-(2-(2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol; (R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol; (3r)-3-[[2-benzyl-6-(3-methoxypropyloxy)-pyridin-3-yl]ethynyl] quinuclidin-3-ol
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C25H30N2O3
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Canonical SMILES |
COCCCOC1=NC(=C(C=C1)C#CC2(CN3CCC2CC3)O)CC4=CC=CC=C4
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InChI |
1S/C25H30N2O3/c1-29-16-5-17-30-24-9-8-21(23(26-24)18-20-6-3-2-4-7-20)10-13-25(28)19-27-14-11-22(25)12-15-27/h2-4,6-9,22,28H,5,11-12,14-19H2,1H3/t25-/m1/s1
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InChIKey |
HVIKCINYHLGLMN-RUZDIDTESA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Squalene synthetase (FDFT1) | Target Info | Inhibitor | [1] |
BioCyc | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | |||
Cholesterol biosynthesis III (via desmosterol) | ||||
Cholesterol biosynthesis I | ||||
Superpathway of cholesterol biosynthesis | ||||
Epoxysqualene biosynthesis | ||||
KEGG Pathway | Steroid biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
PPARA activates gene expression | ||||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Statin Pathway | |||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Activation of Gene Expression by SREBP (SREBF) | ||||
SREBP signalling | ||||
Cholesterol Biosynthesis | ||||
Cholesterol biosynthesis |
References | Top | |||
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REF 1 | Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. Antimicrob Agents Chemother. 2007 Jun;51(6):2123-9. |
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