Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U0HX
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| Former ID |
DIB007209
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| Drug Name |
Molgramostim
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| Synonyms |
Genfulin; Molgramostim (topical, wound healing); Molgramostim (topical, wound healing), GeneScience; GM-CSF (topical, woundhealing), GeneScience; Granulocyte-macrophage colony stimulating factor (topical, wound healing), GeneScience
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| Indication | Autoimmune pulmonary alveolar proteinosis [ICD-11: CB04.31] | Phase 3 | [1] | |
| Wound healing [ICD-11: EL8Y] | Phase 1 | [2] | ||
| Company |
GeneScience Pharmaceuticals Co Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GMCSFR-alpha (CSF2RA) | Target Info | Agonist | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| NetPath Pathway | IL3 Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| Pathway Interaction Database | GMCSF-mediated signaling events | |||
| Alpha9 beta1 integrin signaling events | ||||
| Reactome | GPVI-mediated activation cascade | |||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| RAF/MAP kinase cascade | ||||
| Surfactant metabolism | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | Interleukin-2 signaling | |||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04544293) Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP) (IMPALA-2). U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT02468908) Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects. | |||
| REF 3 | Clinical pipeline report, company report or official report of gensci-china. | |||
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