Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TV1R
|
|||
| Former ID |
DIB019861
|
|||
| Drug Name |
flufenamate
|
|||
| Synonyms |
Flufenamate; 2-[3-(trifluoromethyl)anilino]benzoate; 2-{[3-(trifluoromethyl)phenyl]amino}benzoate; 2-[[3-(trifluoromethyl)phenyl]amino]benzoate; 2pix; AC1MU9L1; GTPL4191; BDBM85514; CHEBI:520819; NSC_27881; ZB003097; CAS_530-78-9; CJ-00698; 2-(3-(trifluoromethyl)phenylamino)benzoate
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C14H9F3NO2-
|
|||
| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)[O-])NC2=CC=CC(=C2)C(F)(F)F
|
|||
| InChI |
1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)/p-1
|
|||
| InChIKey |
LPEPZBJOKDYZAD-UHFFFAOYSA-M
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:520819
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polycystic kidney disease 2-like 1 (TRPP2) | Target Info | Blocker (channel blocker) | [2] |
| Short transient receptor potential channel 6 (TRPC6) | Target Info | Activator | [3] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Endothelins | |||
| Nephrin/Neph1 signaling in the kidney podocyte | ||||
| EPO signaling pathway | ||||
| PAR1-mediated thrombin signaling events | ||||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Platelet homeostasis | ||||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4191). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.