Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TM0Z
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| Former ID |
DNC008601
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| Drug Name |
1H-indole-4,7-dione
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| Synonyms |
Indole-4,7-dione; 1H-Indole-4,7-dione; 20342-64-7; indole-4,7-quinone; CHEBI:51637; Indolequinone, 19; AC1L483C; CHEMBL500863; SCHEMBL1650480; CTK1A3633; BDBM21979; DTXSID20174252; ZINC6091591; 4,7-dihydro-1H-indole-4,7-dione; AKOS006347266
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H5NO2
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| Canonical SMILES |
C1=CC(=O)C2=C(C1=O)C=CN2
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| InChI |
1S/C8H5NO2/c10-6-1-2-7(11)8-5(6)3-4-9-8/h1-4,9H
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| InChIKey |
QMRIWYCCTCNABA-UHFFFAOYSA-N
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| CAS Number |
CAS 20342-64-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:51637
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A. J Med Chem. 2008 May 8;51(9):2634-7. | |||
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