Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0TD1R
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| Drug Name |
Lusutrombopag
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| Synonyms |
LUSUTROMBOPAG; mulpleta; UNII-6LL5JFU42F; 6LL5JFU42F; 2-Propenoic acid, Lusutrombopag [USAN:INN]; SCHEMBL3062
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| Indication | Thrombocytopenia [ICD-11: 3B64] | Approved | [1] | |
| Liver disease [ICD-11: DB90-BD99] | Phase 2 | [2] | ||
| Company |
Shionogi
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| Structure |
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Download2D MOL |
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| Formula |
C29H32Cl2N2O5S
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| Canonical SMILES |
CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(C(=C3)Cl)C=C(C)C(=O)O)Cl
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| InChI |
1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1
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| InChIKey |
NOZIJMHMKORZBA-KJCUYJGMSA-N
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| CAS Number |
CAS 1110766-97-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:136051
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thrombopoietin receptor (MPL) | Target Info | Agonist | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| WikiPathways | Platelet Aggregation (Plug Formation) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | ClinicalTrials.gov (NCT01054443) A Study to Investigate the Efficacy and Safety of S-888711 Tablets Administered to Adult Subjects With Immune Thrombocytopenia (ITP). U.S. National Institutes of Health. | |||
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