Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T7LV
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| Former ID |
DIB003764
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| Drug Name |
LIPO-4
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| Synonyms |
HIV vaccine (four peptide), INRS
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|
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| Drug Type |
Vaccine
|
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 1 | [1] | |
| Company |
INRS-Institut Armand-Frappier
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | T-cell surface glycoprotein CD4 (CD4) | Target Info | . | [2] |
| T-cell surface glycoprotein CD8 (CD8) | Target Info | . | [2] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Antigen processing and presentation | ||||
| Hematopoietic cell lineage | ||||
| T cell receptor signaling pathway | ||||
| Primary immunodeficiency | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| IL12-mediated signaling events | ||||
| CXCR4-mediated signaling events | ||||
| C-MYB transcription factor network | ||||
| IL23-mediated signaling events | ||||
| Arf1 pathway | ||||
| Notch-mediated HES/HEY network | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | Binding and entry of HIV virion | |||
| Phosphorylation of CD3 and TCR zeta chains | ||||
| Translocation of ZAP-70 to Immunological synapse | ||||
| Generation of second messenger molecules | ||||
| PD-1 signaling | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Cytokines and Inflammatory Response | ||||
| Host Interactions of HIV factors | ||||
| Defensins | ||||
| HIV Life Cycle | ||||
| TCR signaling | ||||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00121121) Safety of Intradermal Versus Intramuscular Administration of HIV Lipopeptides in HIV Uninfected Adult Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16). Vaccine. 2013 Sep 13;31(40):4406-15. | |||
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