Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T6DU
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| Former ID |
DIB020589
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| Drug Name |
OAG
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| Synonyms |
1-oleoyl-2-acetyl-sn-glycerol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C23H42O5
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| Canonical SMILES |
CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)OC(=O)C
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| InChI |
1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10+
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| InChIKey |
PWTCCMJTPHCGMS-ZHACJKMWSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Short transient receptor potential channel 2 (TRPC2) | Target Info | Activator | [2] |
| Short transient receptor potential channel 3 (TRPC3) | Target Info | Activator | [3] | |
| Short transient receptor potential channel 6 (TRPC6) | Target Info | Activator | [3] | |
| Short transient receptor potential channel 7 (TRPC7) | Target Info | Activator | [4] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma | |||
| Endothelins | ||||
| Nephrin/Neph1 signaling in the kidney podocyte | ||||
| EPO signaling pathway | ||||
| PAR1-mediated thrombin signaling events | ||||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Platelet homeostasis | |||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2436). | |||
| REF 2 | A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. | |||
| REF 3 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. | |||
| REF 4 | Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70. | |||
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