Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T5VB
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| Former ID |
DIB019630
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| Drug Name |
WO2013110309CA127
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| Synonyms |
A-127; GTPL8169; BDBM50011235
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C20H24N8O2
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| Canonical SMILES |
CCN1C=CC(=N1)NC2=NC=C3C(=N2)N=NN3C4=CC=C(C=C4)C(C)(C)OCCO
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| InChI |
1S/C20H24N8O2/c1-4-27-10-9-17(25-27)22-19-21-13-16-18(23-19)24-26-28(16)15-7-5-14(6-8-15)20(2,3)30-12-11-29/h5-10,13,29H,4,11-12H2,1-3H3,(H,21,22,23,25)
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| InChIKey |
XNAMZBCMLZQBIC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J. 2010 Jun 16;29(12):2082-96. | |||
| REF 2 | Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3. | |||
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