Drug Information
Drug General Information | Top | |||
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Drug ID |
D0T5TU
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Former ID |
DIB004295
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Drug Name |
TPI-1020
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Synonyms |
Nitrobudesonide; NCX-1020; NO-budesonide; Budesonide-21-nitrooxymethylbenzoate
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Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Phase 2 | [1] | |
Company |
NicOx SA
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Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Glucocorticoid receptor (NR3C1) | Target Info | Antagonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Signaling events mediated by HDAC Class II | ||||
FOXA2 and FOXA3 transcription factor networks | ||||
Glucocorticoid receptor regulatory network | ||||
Regulation of Androgen receptor activity | ||||
AP-1 transcription factor network | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
SIDS Susceptibility Pathways | ||||
Nuclear Receptors Meta-Pathway | ||||
Endoderm Differentiation | ||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Adipogenesis | ||||
Circadian Clock | ||||
Nuclear Receptors |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00483743) Safety, Tolerability and PD Activity of Inhaled TPI 1020 Versus Inhaled Budesonide in COPD Patients. U.S. National Institutes of Health. | |||
REF 2 | Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. Br J Pharmacol. 2012 Oct;167(3):515-26. |
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