Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T2EP
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| Former ID |
DIB010329
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| Drug Name |
CLOTURIN
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| Synonyms |
VUFB-15686; N-(2-Chloroethyl)thiocarbamic acid 6-purinyl ester; (2-Chloroethyl)carbamothioic acid S-1H-purin-6-yl ester; 6-[N-(2-Chloroethyl)carbamoyl]thiopurine
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H8ClN5OS
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| Canonical SMILES |
C1=NC2=C(N1)C(=NC=N2)SC(=O)NCCCl
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| InChI |
1S/C8H8ClN5OS/c9-1-2-10-8(15)16-7-5-6(12-3-11-5)13-4-14-7/h3-4H,1-2H2,(H,10,15)(H,11,12,13,14)
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| InChIKey |
OQBORDVFGPUGDV-UHFFFAOYSA-N
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| CAS Number |
CAS 104789-46-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA synthesis (DNA synth) | Target Info | Modulator | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002443) | |||
| REF 2 | Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80. | |||
| REF 3 | 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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