Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T1IJ
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| Former ID |
DAP001287
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| Drug Name |
Oprelvekin
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| Synonyms |
Neumega; Neumega (TN); Oprelvekin (genetical recombination); Oprelvekin (USAN/INN); Oprelvekin (genetical recombination) (JAN)
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| Indication | Thrombocytopenia [ICD-11: 3B64; ICD-10: D69.6, P61.0] | Approved | [1], [2] | |
| Therapeutic Class |
Anticoagulants
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| Company |
Wyeth Pharmaceuticals
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| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D01620 | |||
| SuperDrug ATC ID |
L03AC02
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 11 receptor alpha (IL11RA) | Target Info | Binder | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Panther Pathway | Interleukin signaling pathway | |||
| WikiPathways | Interleukin-11 Signaling Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6971). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71. | |||
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