Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T0LM
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| Former ID |
DAP000492
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| Drug Name |
Pirenzepine
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| Synonyms |
Gasteril; Gastrotsepin; Gastrozepin; Pirenzepin; Pirenzepina; Pirenzepinum; Pyrenzepine; Ulcosan; Pirenzepine Gastrozepin; Gastrozepin (TN); L-S 519; Pirenzepina [INN-Spanish]; Pirenzepine (INN); Pirenzepine [INN:BAN]; Pirenzepinum [INN-Latin]; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Peptic ulcer [ICD-11: DA61] | Approved | [1], [2] | |
| Therapeutic Class |
Antiulcer Agents
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| Company |
Boehringer Ingelheim
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| Structure |
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Download2D MOL |
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| Formula |
C19H21N5O2
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| Canonical SMILES |
CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
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| InChI |
1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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| InChIKey |
RMHMFHUVIITRHF-UHFFFAOYSA-N
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| CAS Number |
CAS 28797-61-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9711, 5518525, 7980332, 8152981, 11111661, 11111662, 11113363, 11335302, 11360541, 11364272, 11366834, 11369396, 11372544, 11373933, 11377558, 11461513, 11466157, 11467277, 11485230, 11485853, 11489233, 11491268, 11492252, 11495192, 14852009, 26751604, 29223929, 46509029, 47211770, 47216642, 47365035, 47365036, 47515172, 47588849, 47959578, 47959579, 48110309, 48334341, 48416446, 49698919, 50034085, 50100327, 50104261, 50139450, 50423922, 57322487, 81065495, 81093320, 85209239, 85787888
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| ChEBI ID |
CHEBI:8247
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| SuperDrug ATC ID |
A02BX03
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| SuperDrug CAS ID |
cas=028797617
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 328). | |||
| REF 2 | Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol. 2003 May;41(5):671-7. | |||
| REF 3 | Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31. | |||
| REF 4 | The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma. Pneumonol Alergol Pol. 1992;60(11-12):32-6. | |||
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