Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SY7H
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| Former ID |
DIB012380
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| Drug Name |
IDX-184
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| Synonyms |
B-102; B-184; B-299; IDX-102; Next-generation nucleotide polymerase inhibitors (HCV infection), Idenix; Next-generation nucleotide polymerase inhibitors (hepatitis C virus infection), Idenix; 2'-methyl guanosine prodrug (hepatitis C virus infection), Idenix
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Phase 1/2 | [1] | |
| Company |
Idenix Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C25H35N6O9PS
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| Canonical SMILES |
CC1(C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(NCC4=CC=CC=C4)OCCSC(=O)C(C)(C)CO)O)O
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| InChI |
1S/C25H35N6O9PS/c1-24(2,13-32)22(35)42-10-9-38-41(37,28-11-15-7-5-4-6-8-15)39-12-16-18(33)25(3,36)21(40-16)31-14-27-17-19(31)29-23(26)30-20(17)34/h4-8,14,16,18,21,32-33,36H,9-13H2,1-3H3,(H,28,37)(H3,26,29,30,34)/t16-,18-,21-,25-,41?/m1/s1
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| InChIKey |
FGHMGRXAHIXTBM-TWFJNEQDSA-N
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| CAS Number |
CAS 1036915-08-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus Non-structural 5 (HCV NS5) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00807001) Double-Blind, Dose-Escalation Study of IDX184 in Chronic Hepatitis C Treatment-Naive Subjects. U.S. National Institutes of Health. | |||
| REF 2 | Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus. Antimicrob Agents Chemother. 2012 June; 56(6): 3359-3368. | |||
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