Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SR4T
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| Former ID |
DIB013630
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| Drug Name |
PHENSERINE TARTRATE
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| Synonyms |
N-Phenylcarbamic acid (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl ester L-tartrate; (-)-5-O-(N-Phenylcarbamoyl)eseroline L-tartrate
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Preclinical | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C24H29N3O8
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| Canonical SMILES |
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C.C(C(C(=O)O)O)(C(=O)O)O
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| InChI |
1S/C20H23N3O2.C4H6O6/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14;5-1(3(7)8)2(6)4(9)10/h4-10,13,18H,11-12H2,1-3H3,(H,21,24);1-2,5-6H,(H,7,8)(H,9,10)/t18-,20+;1-,2-/m11/s1
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| InChIKey |
XKKPTCVQEJZDGT-PWUAAHBCSA-N
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| CAS Number |
CAS 156910-61-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10261477, 14753533, 14900124, 26756608, 33513596, 46511524, 50040339, 57397101, 80863817, 87219185, 90341153, 93308100, 103064548, 103080958, 103274646, 113454006, 117554826, 121361311, 126522384, 127337068, 127337069, 134341073, 135169732, 135698170, 141832076, 152106740, 162247997, 162767949, 163564477, 172113464, 175426894, 175612430, 198973050, 198975219, 204361976, 227737638, 243695745, 252156912
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2], [3] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012344) | |||
| REF 2 | An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul;2(3):281-90. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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