Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SN1T
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| Former ID |
DIB004681
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| Drug Name |
Nikkomycin Z
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| Synonyms |
SP-920704
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| Drug Type |
Small molecular drug
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| Indication | Candidiasis [ICD-11: 1F23] | Phase 1/2 | [1] | |
| Company |
Bayer AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H25N5O10
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| Canonical SMILES |
CC(C(C1=NC=C(C=C1)O)O)C(C(=O)NC(C2C(C(C(O2)N3C=CC(=O)NC3=O)O)O)C(=O)O)N
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| InChI |
1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1
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| InChIKey |
WWJFFVUVFNBJTN-VHDFTHOZSA-N
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| CAS Number |
CAS 59456-70-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:623918
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Chitin synthase 3 (Candi CHS3) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00614666) Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment. U.S. National Institutes of Health. | |||
| REF 2 | Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicans. Yeast. 2002 Mar 15;19(4):341-9. | |||
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