Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SH2X
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| Former ID |
DIB011723
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| Drug Name |
Amocarzine
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| Synonyms |
Phenthiourezine; Thiocarbamazine; CGP-6140; S-80016
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| Drug Type |
Small molecular drug
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| Indication | Helminth infection [ICD-11: 1F90.0; ICD-10: A00-B99; ICD-9: 001-139] | Phase 3 | [1] | |
| Company |
Novartis AG
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| Structure |
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Download2D MOL |
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| Formula |
C18H21N5O2S
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| Canonical SMILES |
CN1CCN(CC1)C(=S)NC2=CC=C(C=C2)NC3=CC=C(C=C3)[N+](=O)[O-]
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| InChI |
1S/C18H21N5O2S/c1-21-10-12-22(13-11-21)18(26)20-16-4-2-14(3-5-16)19-15-6-8-17(9-7-15)23(24)25/h2-9,19H,10-13H2,1H3,(H,20,26)
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| InChIKey |
UFLRJROFPAGRPN-UHFFFAOYSA-N
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| CAS Number |
CAS 36590-19-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:38946
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment. Ann Trop Med Parasitol. 1997 Apr;91(3):281-96. | |||
| REF 2 | Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211. | |||
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