Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0SE9S
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| Former ID |
DIB007289
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| Drug Name |
SCH-221510
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| Synonyms |
SCH-225288; SCH-655842; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence); NOP agonists (pain, anxiety, cough, urinary incontinence), Merck & Co; NOP receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Nociceptin opioid peptide receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence), Merck & Co; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence),Schering-Plough; ORL1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Opioid receptor-like 1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Investigative | [1] | |
| Company |
Schering-Plough Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H31NO
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| Canonical SMILES |
CC1=CC=CC=C1C(C2=CC=CC=C2C)N3C4CCC3CC(C4)(C5=CC=CC=C5)O
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| InChI |
1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3
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| InChIKey |
LOSJNRBXNQTUNT-UHFFFAOYSA-N
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| CAS Number |
CAS 322473-89-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nociceptin receptor (OPRL1) | Target Info | Agonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). | |||
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