Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S9XO
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| Former ID |
DIB020328
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| Drug Name |
mercaptoacrylate inhibitor of calpain 1
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| Synonyms |
mercaptoacrylate inhibitor of calpain 1; GTPL8570; CHEMBL3221938; (Z)-3-(5-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C11H8BrNO2S
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| Canonical SMILES |
C1=CC2=C(C=C1Br)C(=CN2)C=C(C(=O)O)S
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| InChI |
1S/C11H8BrNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
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| InChIKey |
RLEKFRNXGFHPHZ-KMKOMSMNSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calpain-2 (CAPN2) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| Apoptosis | ||||
| Alzheimer's disease | ||||
| Reactome | Degradation of the extracellular matrix | |||
| WikiPathways | Focal Adhesion | |||
| Integrated Pancreatic Cancer Pathway | ||||
| Alzheimers Disease | ||||
| Integrin-mediated Cell Adhesion | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8570). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). | |||
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