Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S5IR
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| Drug Name |
Zuranolone
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| Synonyms |
SAGE-217; HARRKNSQXBRBGZ-GVKWWOCJSA-N; SCHEMBL16189866; HY-103040; CS-0023489; 1632051-40-1
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| Indication | Postpartum depression [ICD-11: 6E20.0] | Approved | [1] | |
| Essential tremor or related tremors [ICD-11: 8A04.1; ICD-10: G25.0] | Phase 2 | [2] | ||
| Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Phase 2 | [3] | ||
| Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 2 | [2] | ||
| Company |
Sage Therapeutics Cambridge, MA
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| Structure |
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Download2D MOL |
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| Formula |
C25H35N3O2
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| Canonical SMILES |
CC1(CCC2C(C1)CCC3C2CCC4(C3CCC4C(=O)CN5C=C(C=N5)C#N)C)O
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| InChI |
1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
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| InChIKey |
HARRKNSQXBRBGZ-GVKWWOCJSA-N
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| CAS Number |
CAS 1632051-40-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217369 | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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