Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0S5CH
|
|||
Former ID |
DIB013645
|
|||
Drug Name |
Metaxalone
|
|||
Synonyms |
Skelaxin
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Pain [ICD-11: MG30-MG3Z] | Approved | [1], [2] | |
Company |
Elan Corp plc
|
|||
Structure |
Download2D MOL |
|||
Formula |
C12H15NO3
|
|||
Canonical SMILES |
CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C
|
|||
InChI |
1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
|
|||
InChIKey |
IMWZZHHPURKASS-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 1665-48-1
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
10136, 223524, 443232, 5454948, 7847838, 8161614, 10510116, 11341927, 11362110, 11364635, 11367197, 11369759, 11372770, 11374303, 11377921, 11484331, 11487512, 11488364, 11491481, 11492427, 11495555, 14797958, 26612681, 26679615, 26748938, 26748939, 29283414, 46506253, 47217064, 47217065, 47440556, 48416228, 50001705, 50107490, 57329020, 78100200, 81041143, 85787981, 92124711, 92307892, 99358106, 103737291, 104337209, 117601598, 124637427, 125342557, 126652570, 126691493, 128190925, 131301288
|
|||
ChEBI ID |
CHEBI:6797
|
|||
ADReCS Drug ID | BADD_D01400 |
Interaction between the Drug and Microbe | Top | |||
---|---|---|---|---|
The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.828; p = 0.007). | |||
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.76; p = 0.014). | |||
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.654; p = 0.005). | |||
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.654; p = 0.044). | |||
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.632; p = 0.047). | |||
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.694; p = 0.017). | |||
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.764; p = 0.008). | |||
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.633; p = 0.039). | |||
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.483; p = 0.021). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Bacteroides pectinophilus ATCC 43243
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.525; p = 0.034). | |||
Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.579; p = 0.048). | |||
Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Metaxalone can be metabolized by Clostridium sp. (log2FC = -0.53; p = 0.032). |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7609). | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.